Datasheet

Peptide-affinity Purified Polyclonal Antibody to NALP7 Cat.No IMG-6357A Description NALP7 Format Purified, Peptide Affinity Unit 0.1 mg Price(USD) 236.00 MSDS Catalog No : IMG-6357A Contents : 100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. Isotype : Rabbit Ig Purification : Antigen Affinity Chromatography Species : Human, Rhesus Monkey Host : Rabbit Application Western blot analysis: 0.25-1.0 ug/ml Storage Store at 4°C, stable for 6 months. For long-term storage, aliquot and store at -20°C. Recommended Positive Control : Human Liver lysate Background NALP7 is a 980 amino acid containing short NALP belonging to the NLRP family with a DAPIN domain, nine LRR (leucine-rich) repeats and a NACHT domain. NALP7 is usually induced by LPS and IL-1B in peripheral blood mononuclear cells. A PYRIN-containing APAF-1-like protein, NALP7 directly interacts with CASP1 and IL-1B and acts as a feedback regulator of CASP1/caspase-1-dependent interleukin-1 beta secretion. It may play a crucial role in cell proliferation. Expressed in numerous tissues including uterus and ovary, with low levels in heart and brain but not detected in skeletal muscle. Defects in NLRP7 are the cause of hydatidiform mole (HYDM), an abnormal human pregnancy with no embryo and cystic degeneration of placental villi. Antigen A synthetic peptide corresponding to amino acids 106-122 (GDAEEDSELAKPGEKEG) human NALP7 was used as the immunogen, GenBank No. NP_001120727.1. Application Notes The amino acid sequence used as immunogen is 100% homologous in human and rhesus monkey. Genebank Info (Protein) AAO18158   Western blot analysis of NALP7 in human liver lysate in the 1) absence and 2) presence of immunizing peptide using IMG-6357A at 0.25 ug/ml.  IMGENEX’s goat anti-rabbit Ig HRP secondary antibody (IMGENEX, 20301) and PicoTect ECL substrate solution (IMGENEX, 10087K) were used for this test. ffsdf Related Products Reference 1. Tschopp, J. et al. Nature Rev. Molec. Cell Biol. 4:95-104 (2003). 2. Okada, K. et al. Cancer Sci. 95:949-954 (2004). 3. Kinoshita, T. et al. J. Biol. Chem. 280:21720-21725 (2005). 4. Murdoch, S. et al. Nature Genet. 38:300-302 (2006). Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.

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IMG-6357A [Peptide-affinity Purified Polyclonal Antibody to NALP7 ]

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