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Product : Antibody >> DNA Methylation & Rep.. , New Antibodies >> Furin
      
 

Polyclonal Antibody to Furin

 
Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
IMG-6395A
FurinPurified
0.1 mg
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Catalog No: IMG-6395A
Imgenex is now a part of Novus Biologicals! All orders, billing and shipments will be received from Novus. Please contact Novus directly for any questions – novus@novusbio.com. To insure proper processing of you order, please insure that your purchase orders show Novus Biologicals as the vendor.
Contents: 100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Isotype: Rabbit IgG
Purification: Protein A Chromatography
Species: Chimpanzee, Cow, Dog, Horse, Human, Mouse, Rat, Rhesus Monkey
Predicted React: Chicken, Opossum, Xenopus
Host: Rabbit
Application: IHC (paraffin): 5 ug/ml
Storage: Store at 4°C, stable for 6 months. For long-term storage, aliquot and store at -20°C.
 

Background
Furin, also known as Paired basic amino acid residue cleaving enzyme, is a 794 amino acid containing membrane associated protein circulating between the trans-Golgi network and cell surface. It belongs to the peptidase S8 family and Furin subfamily with a homo B/P domain. Known to represent the ubiquitous endoprotease activity within constitutive secretory pathways, Furin, a calcium-dependent serine endoprotease, can efficiently cleave precursor proteins at their paired basic amino acid processing sites (RX (K/R) R consensus motif). This proprotein convertase enzyme processes latent precursor proteins into their biologically active products and is important in the release of albumin and complement component C3 from their respective precursors and in the physiologic processing of proparathyroid hormone, von Willebrand factor, insulin receptor, TGF1B, hepatocyte growth factor, C propeptide of collagen type V, alpha 1, NOTCH signaling proteins, certain viral envelope glycoproteins and ED1. Ubiquitous expression of Furin is seen in most of the tissues. It may also play a role in tumor progression and maintainance of immune tolerance.

Antigen
A portion of amino acids 740-790 of human Furin was used as the immunogen.

Application Notes
The amino acid sequence used as immunogen is 100% homologous in human, wild boar, horse, mouse, chimpanzee, rhesus monkey, dog and sheep, 94% homologous in opossum and 77% homologous in chicken and Xenopus.

Genebank Info (Protein): NP_002560
Gene ID: 5045
SwissProt: P09958
 
Furin

Immunohistochemical analysis of Furin in formalin-fixed, paraffin-embedded human kidney tissue using an isotype control (top left) and IMG-6395A (bottom left, right) at 5 ug/ml.

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Reference
1. Pesu, M. et al. Nature. 455:246-250 (2008).
2. Blanchette, F. et al. J. Clin. Invest. 99:1974-1983 (1997).
3. Hendy, GN. J. Biol. Chem. 270:9517-9525 (1995).


Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.


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