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Polyclonal Antibody to NALP11 |
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| Catalog No: |
IMG-6443A |
| Contents: |
100 ug antibody in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Isotype: |
Rabbit IgG |
| Purification: |
Protein A Chromatography |
| Species: |
Human |
| Predicted React: |
Mouse, New World monkey |
| Host: |
Rabbit |
| Application: |
IHC (paraffin): 5 ug/ml |
| Storage: |
Store antibody at 4°C, stable for 6 months. For long-term storage, aliquot and store at -20°C. |
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Background
NALP11 is a 1033 amino acid containing cytoplasmic protein belonging to the NLRP family with a DAPIN domain, six LRR (leucine-rich) repeats and a NACHT domain. Reports suggest that it is a short NALP involved in inflammation potential. NALP proteins are implicated in the activation of proinflammatory caspases (e.g., CASP1) via their involvement in multiprotein complexes called inflammasomes. The DAPIN domain is necessary and sufficient for suppression of NF-kappa B activation induced by TNF and for inducing IL-1B secretion in collaboration with Caspase-1. It is involved in interaction with PYCARD. |
Antigen
A portion of amino acids 850-900 of human NALP11 was used as the immunogen. |
Application Notes
The amino acid sequence used as immunogen is 100% homologous in human, 88% homologous in monkey, and 62% homologous in mouse. |
Genebank Info (Protein)
NP_659444 |
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Immunohistochemical analysis of NALP11. Formalin-fixed, paraffin-embedded human liver tissue probed with an isotype control antibody (top) and NALP11 antibody (bottom) at 5 ug/ml. |
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Reference
1. Tschopp, J. et al. Nature Rev. Molec. Cell Biol. 4:95-104 (2003).
2. Inohara, N. et al. Nature Rev. 3:371-382 (2003).
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Research purposes only.
Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.
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