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Product : Antibody >> Inflammation , Innate Immunology , Regulatory T Cells (Treg) , Th17 Antibodies >> IL-17A
      
 

Monoclonal Antibody to IL-17A (Clone 4K5F6)

 
Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
IMG-6545A
IL-17APurified
0.1 mg
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Catalog No: IMG-6545A
Imgenex is now a part of Novus Biologicals! All orders, billing and shipments will be received from Novus. Please contact Novus directly for any questions ľ novus@novusbio.com. To insure proper processing of you order, please insure that your purchase orders show Novus Biologicals as the vendor.
Contents: 100 ug IL-17A antibody in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Isotype: Mouse IgG2a, Kappa
Clone: 4K5F6
Purification: Protein G Chromatography was used to purify the IL-17A antibody.
Species: Human
Host: Mouse
Application: Western blot analysis: use IL-17A antibody at 0.2-2 ug/ml
Storage: Store IL-17A antibody at 4░C, stable for 6 months. For long-term storage, aliquot and store at -20░C.
 

Background
Interleukin 17 (IL-17) is a pro-inflammatory cytokine produced by a subset of T helper cells that develops distinct from the Th1- and Th2- cell differentiation pathways. IL-17, also known as CTLA-8, stimulates induction of other pro-inflammatory cytokines TNF alpha, IL-1 beta, IL-6, and IL-8, and reports strongly suggest the involvement of IL-17 in several chronic inflammatory diseases such as rheumatoid arthritis, psoriasis and multiple sclerosis. TGF-▀ (differentiation) and IL-23 (expansion) are required for induction and maintenance of Th17 (IL-17 producing) cells, which in turn induce the other pro-inflammatory cytokines. IL-17 (~32kDa) protein is produced and exists as a homo-dimer, has homology to a herpes virus early protein, is one of the six members (IL-17A-F) of this cytokine family, and is well characterzed and highly expressed by activated effector memory T cells.

Antigen
A portion of amino acidsá1-75 of humanáIL-17A was used as the immunogen for the antibody.

Application Notes
The amino acid sequence used as immunogen is 100% homologous in human, 97% homologous in chimpanzee and 95% homologous in rhesus monkey.

View additional IL-17A antibodies

View additional IL-17 antibodies

Genebank Info (Protein): NP_002181
Gene ID: 3605
SwissProt: Q16552
 
IL-17A Antibody WB

Western blot analysis of 1) human, 2) mouse and 3) rat full-length recombinant IL-17A protein (100 ng/lane) using IL-17A antibody at 0.2 ug/ml.

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Reference
1. Chen Z and O’Shea JJ 2008 Immunol Res 41: 87-102
2. Mangan PR et al 2006 Nature 441: 231-234
3. Veldhoen M et al 2006 Immunity 24:179-189


Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.


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