|
|
|
| |
Monoclonal Antibody to IL-17F (Clone 4H1629) |
|
|
| |
|
|
| |
|
| Catalog No: |
IMG-6579A |
| Contents: |
100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Isotype: |
Mouse IgG1, Kappa |
| Clone: |
4H1629 |
| Purification: |
Protein G Chromatography |
| Species: |
Human |
| Host: |
Mouse |
| Application: |
IHC (paraffin): 5 ug/ml
Western blot analysis: 0.5-2 ug/ml |
| Storage: |
Store at 4°C, stable for 6 months. For long-term storage, aliquot and store at -20°C. |
|
 |
|
|
|
|
|
|
Background
Interleukin 17 (IL-17) is a pro-inflammatory cytokine produced by a subset of T helper cells that develops distinct from the Th1- and Th2- cell differentiation pathways. IL-17, also known as CTLA-8, stimulates induction of other pro-inflammatory cytokines TNF alpha, IL-1 beta, IL-6, and IL-8, and reports strongly suggest the involvement of IL-17 in several chronic inflammatory diseases such as rheumatoid arthritis, psoriasis and multiple sclerosis. TGF-ß (differentiation) and IL-23 (expansion) are required for induction and maintenance of Th17 (IL-17 producing) cells, which in turn induce the other pro-inflammatory cytokines. IL-17 (~32kDa) protein is produced and exists as a homo-dimer, has homology to a herpes virus early protein, is one of the six members (IL-17A-F) of this cytokine family, and is well characterzed and highly expressed by activated effector memory T cells. |
Antigen
Full-length recombinant human IL-17F was used as the immunogen. |
Genebank Info (Protein)
NP_443104 |
| |
|
Western blot analysis of IL-17F in 1) human, 2) mouse and 3) rat full-length recombinant IL-17F protein (20 ng/lane) using IMG-6579A at 0.5 ug/ml. |
|
|
|
|
Immunohistochemical analysis of IL-17F in formalin-fixed, paraffin-embedded human colon tissue using an isotype control (top left) and IMG-6579A (bottom left, right) at 5 ug/ml. |
|
|
|
|
|
| - |
 |
|
Reference
1. Chen Z and O’Shea JJ 2008 Immunol Res 41: 87-102
2. Mangan PR et al 2006 Nature 441: 231-234
3. Veldhoen M et al 2006 Immunity 24:179-189
|
|
|
|
Research purposes only.
Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.
|
|
|
|
|
