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Product : Antibody >> Inflammation , Innate Immunology , New Antibodies , Regulatory T Cells (Treg) , Th17 Antibodies >> IL-17F
      
 

Monoclonal Antibody to IL-17F (Clone 4H1629)

 
Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
IMG-6579A
IL-17FPurified
0.1 mg
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Catalog No: IMG-6579A
Imgenex is now a part of Novus Biologicals! All orders, billing and shipments will be received from Novus. Please contact Novus directly for any questions – novus@novusbio.com. To insure proper processing of you order, please insure that your purchase orders show Novus Biologicals as the vendor.
Contents: 100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Isotype: Mouse IgG1, Kappa
Clone: 4H1629
Purification: Protein G Chromatography
Species: Human
Host: Mouse
Application: IHC (paraffin): 5 ug/ml
Western blot analysis: 0.5-2 ug/ml
Storage: Store at 4°C, stable for 6 months. For long-term storage, aliquot and store at -20°C.
 

Background
Interleukin 17 (IL-17) is a pro-inflammatory cytokine produced by a subset of T helper cells that develops distinct from the Th1- and Th2- cell differentiation pathways. IL-17, also known as CTLA-8, stimulates induction of other pro-inflammatory cytokines TNF alpha, IL-1 beta, IL-6, and IL-8, and reports strongly suggest the involvement of IL-17 in several chronic inflammatory diseases such as rheumatoid arthritis, psoriasis and multiple sclerosis. TGF-ß (differentiation) and IL-23 (expansion) are required for induction and maintenance of Th17 (IL-17 producing) cells, which in turn induce the other pro-inflammatory cytokines. IL-17 (~32kDa) protein is produced and exists as a homo-dimer, has homology to a herpes virus early protein, is one of the six members (IL-17A-F) of this cytokine family, and is well characterzed and highly expressed by activated effector memory T cells.

Antigen
Full-length recombinant human IL-17F was used as the immunogen.

Genebank Info (Protein): NP_443104
Gene ID: 112744
SwissProt: Q96PD4
 
IL-17F Antibody

Western blot analysis of IL-17F in 1) human, 2) mouse and 3) rat full-length recombinant IL-17F protein (20 ng/lane) using IMG-6579A at 0.5 ug/ml.

IL-17F Antibody IMG-6579A

Formalin-fixed, paraffin-embedded human stomach tissue (IMH-343) stained with IL-17F antibody (5 ug/ml), peroxidase-conjugate and DAB chromogen.

Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM sodium citrate buffer, pH 6.0 for 10-20 min followed by cooling at RT for 20 min.

IL-17F

Immunohistochemical analysis of IL-17F in formalin-fixed, paraffin-embedded human colon tissue using an isotype control (top left) and IMG-6579A (bottom left, right) at 5 ug/ml.

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Reference
1. Chen Z and O’Shea JJ 2008 Immunol Res 41: 87-102
2. Mangan PR et al 2006 Nature 441: 231-234
3. Veldhoen M et al 2006 Immunity 24:179-189


Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.


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