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Polyclonal Antibody to AP3 subunit M1 |
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| Catalog No: |
IMG-6721A |
| Contents: |
100 µg antibody in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Isotype: |
Rabbit IgG |
| Purification: |
Protein A Chromatography |
| Species: |
Carolina anole, Chicken, Chinese Hamster, Cow, Dog, Horse, Human |
| Host: |
Rabbit |
| Application: |
Western blot analysis: 3-5 ug/ml |
| Storage: |
Store antibody at 4°C, stable for 6 months. For long term storage, aliquot and store at -20°C. |
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Background
Adaptor Protein 3 complex subunit mu-1 (AP3M1) belongs to the adaptor complexes medium subunit family and it contains one MHD (mu homology) domain. AP3 is a hetero-tetrameric protein complex composed of four subunits: two large (delta and beta3), one medium (mu3a/M1), and one small (sigma 3). Mutations in one of the large subunits of AP3 have been associated with the Hermansky-Pudlak syndrome, a genetic disorder characterized by defective lysosome-related organelles. It is also reported that AP3, is responsible for the trafficking of TLR9 to recognize viral nucleic acid. AP3 is also involved with a susceptibility gene for schizophrenia, dysbindin. |
Antigen
The immunogen for this antibody was a portion of amino acid 140-190 of human AP3 subunit M1. |
Application Notes
The amino acid sequence used as immunogen is 100% homologous in human, rhesus monkey, wild pig, dog, cow, horse, opossum, orangutan, mouse, rat, wild turkey, zebrafinch, chicken, new world monkey, chinese hamster, macaque, rabbit, carolina anole and platypus. |
Genebank Info (Protein)
AAD20446 |
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Western blot analysis using AP3 subunit M1 antibody. Lysate from human Daudi cells in the 1) absence and 2) presence of immunizing peptide probed with AP3 subunit M1 antibody at 4 ug/ml. |
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Reference
1. Sasai, M. et al. Science 329: 1530-1534 (2010).
2. Hashimoto, R. et al. Neurosci. Res. 65: 113-115 (2009).
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Research purposes only.
Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.
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