Product : Antibody >> Antigen Affinity Purified , Neurobiology , New Antibodies , Nuclear & Cytoplasmic.. , Phosphospecific Antibodie.. >> Synapsin I

Affinity Purified Synapsin I Polyclonal Antibody

Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
Synapsin IPurified, Peptide Affinity
0.05 mL
Catalog No: IMG-687
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Contents: 10 ug antibody vial; lyophilized from 5 mM ammonium bicarbonate. The antibody should be reconstituted in 50 ul phosphate buffered saline (PBS:137 mM NaCl, 7.5 mM Na2HPO4, 2.7 mM KCl, 1.5 mM KH2PO4, pH 7.4) before use.  Adequate amount of material to conduct 10 mini Western Blots.
Isotype: Rabbit IgG
Clone: N/A
Purification: Antigen Affinity Chromatography
Species: Human, Mouse, Rat
Host: Rabbit
Application: WB, IHC (cryosections), IP, IF/ICC
Storage: The lyophilized antibody can be stored at -20C and is stable for at least 2 years. The antibody should be reconstituted in 50 ul phosphate buffered saline (PBS:137 mM NaCl, 7.5 mM Na2HPO4, 2.7 mM KCl, 1.5 mM KH2PO4, pH 7.4) before use. After reconstitution the antibody should be aliquot and stored at -20C.
Positive Control:
rat brain

Synapsin I plays a key role in synaptic plasticity in brain. This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. In addition to its role in plasticity, the expression of synapsin I is a precise indicator of synapse formation. Thus synapsin I immunocytochemistry provides a valuable tool for the study of synaptogenesis. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation.

This antibody was developed against Synapsin I native protein purified from bovine brain. The antibody was purified on a Synapsin I affinity column.

Application Notes
In rat brain, a ~78 kDa doublet is observed. Immunolabeling blocked by preadsorption of antibody with Synapsin I. Human, mouse and rat have 100% amino acid sequence for Synapsin I. Antibody dilutions and tissue load should be based on tissue type and expected expression level.

Synapsin I Antibody

Western Blot of 10 ug of rat brain lysate showing specific immunolabeling of the ~78 kDa Synapsin I doublet.


1. Stone, L.M., Browning M.D. and Finger T.E., J. Neurosci. 14 (1994) 301 ? 309.
2. Jovanovic, J.N., Sihra, T.S., Nairn, A.C., Hemmings, H.C., Jr., Greengard, P., and Czernik, A.J., J. Neurosci., 21 (2001) 7944 7953.
3. Kao, H.T., Song, H.J., Porton, B., Ming, G.L., Hoh, J., Abraham, M., Czernik, A.J., Pieribone, V.A., Poo, M.M., and Greengard,P., Nature Neurosci., 5 (2002) 431 - 437.
4. Nayak, A.C., Moore, C.I. and Browning, M.D., Proc. Natl. Acad. Sci. (USA) 93 (1996) 15,451 -15,456. 5.Browning, M.D., Dudek, E.M., Rapier, J.L., Leonard, S., and Freedman, R., Biol. Psychiatry 34 (1993) 529 - 535.

Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.






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