Affinity Purified Synapsin I Polyclonal Antibody

Background
Synapsin I plays a key role in synaptic plasticity in brain. This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. In addition to its role in plasticity, the expression of synapsin I is a precise indicator of synapse formation. Thus synapsin I immunocytochemistry provides a valuable tool for the study of synaptogenesis. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation.

Antigen
This antibody was developed against Synapsin I native protein purified from bovine brain. The antibody was purified on a Synapsin I affinity column.

Application Notes
In rat brain, a ~78 kDa doublet is observed. Immunolabeling blocked by preadsorption of antibody with Synapsin I. Human, mouse and rat have 100% amino acid sequence for Synapsin I. Antibody dilutions and tissue load should be based on tissue type and expected expression level.

Reference
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