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Product : Antibody >> G-Protein Coupled Recepto.. , G-Protein Coupled Recepto.. , Neurobiology , Stem Cell Markers >> CXCR4 (CXC Chemokine Receptor 4)
      
 

Peptide-affinity Purified Polyclonal Antibody to CXC Chemokine Receptor 4 (CXCR4)

 
Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
IMG-71224
CXCR4 (CXC Chemokine Receptor 4)Purified, Peptide Affinity
0.05 mg
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Catalog No: IMG-71224
Imgenex is now a part of Novus Biologicals! All orders, billing and shipments will be received from Novus. Please contact Novus directly for any questions novus@novusbio.com. To insure proper processing of you order, please insure that your purchase orders show Novus Biologicals as the vendor.
Contents: 0.05 mg of purified antibody at a concentration of 1 mg/ml. Phosphate buffered saline, pH 7.7, containing 0.01% sodium azide
Isotype: Rabbit IgG
Clone: N/A
Purification: Antigen Affinity Chromatography
Species: Human, Mouse, Rat
Host: Rabbit
Application: IHC (paraffin): 9-14 ug/ml
Storage: Store at -20C. For long term storage, store at -70C
Recommended
Positive Control:
Human Brain, Neurons and glia
 

Background
CXCR4, a Chemokine Receptor involved in organ vascularization, neuronal cell migration, and patterning of the central nervous system during development. It binds stromal cell-derived factor 1 (SDF1, also called PBFS) and mediates migration of resting leukocytes and is unique in homing hematopoietic progenitors to bone marrow. These properties suggest that CXCR4 is involved in tumor cell migration and local tumor invasion. It is also an HIV-1 fusion co-factor that allows HIV-1 invasion in diverse human cell types. Although this receptor was initially called Neuropeptide Y3 Receptor, it does not respond to neuropeptide Y. CXCR4 has two isoforms that are produced by alternative splicing. CXCR4 has been reported to be expressed in cells of the immune and central nervous systems. It is highly expressed in brain and heart, and in white blood cells, vascular endothelial cells, and umbilical cord endothelial cells. In brain tumors, CXCR4 is expressed in regions of angiogenesis and degenerative, necrotic, and microcystic changes (Rempel et al., 2000). ESTs have been isolated from a wide variety of tissue libraries, particularly uterus, kidney, lung, tonsil, and brain.

Antigen
Synthetic peptide corresponding to the 3rd cytoplasmic domain of human CXC Chemokine Receptor 4 (CXCR4)

Genebank Info (Protein): NP_001008540
Gene ID: 7852
SwissProt: P61073
 
CXCR4 (CXC Chemokine Receptor 4) Antibody

IHC analysis of brain (neurons and glia) using IMG-71224 at 9 ug/ ml.

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Reference


Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.


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