Peptide-affinity Purified Polyclonal Antibody to PTPMT1 (Protein Tyrosine Phosphatase, Mitochondrial 1)

Background
Principal Names- PLIP; PNAS-129; NDUFS3; PTPMT1; LOC4722; LOC114971; snawjaby;  PTPMT1 is a nuclear encoded PTP that resides exclusively in mitochondria (named PTPMT1 for tyrosine phosphatase localized to the mitochondrion). This localization is deduced by the presence of an N-terminal motif recognized by a mitochondrial translocase. PTPMT1 is anchored to the matrix face of the inner mitochondrial membrane, where the electron transport chain, proton pumps, and ATP synthase reside. This places PTPMT1 at the heart of the enzymatic machinery responsible for oxidative ATP synthesis. It also represents the first PTP to be exclusively located to this organelle.  Members of the PTEN subfamily have poor phosphatase activity on proteins and prefer lipid substrates. PTPMT1 exhibits strong activity against the phosphoinositide PI5P in vitro, but no evidence of changes in the mitochondrial levels of PI5P following the knockdown of PTPMT1 have been seen. The lipid phosphatase characteristics of PTPMT1 and its targeting to the inner mitochondrial membrane raise questions regarding its natural substrate and specific function in mitochondria.

Antigen
Synthetic peptide corresponding to the internal domain of human Protein Tyrosine Phosphatase, Mitochondrial 1 (PTPMT1).

Application Notes
The peptide used to generate this antibody is homologous to the following species at the indicated percentages: rhesus monkey, 100%, rat, 89%, mouse, 89%, dog, 100%, cow, 79%.

Genebank Info (Nucleotide): BC014048

Reference
1. Nature 2001 Feb. 409:685-90Functional annotation of a full-length mouse cDNA collection. Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y