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Peptide-affinity Purified Polyclonal Antibody to FAK1 (Focal Adhesion Kinase 1) |
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| Catalog No: |
IMG-71987 |
| Contents: |
0.05 mg of purified antibody in phosphate buffered saline containing 0.1% sodium azide |
| Isotype: |
Rabbit IgG |
| Clone: |
N/A |
| Purification: |
Antigen Affinity Chromatography |
| Species: |
Human |
| Host: |
Rabbit |
| Application: |
IHC (paraffin): 2 µg/ml |
| Storage: |
Store at -20°C. For long term storage, store at -70°C |
Recommended
Positive Control: |
Human ductal and lobular epithelium |
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Background
Principal Names- PTK2, EC 2.7.10.2, FADK, FAK, FAK1, PP125FAK, fadk1, focal adhesion kinase, focal adhesion kinase 1, p125FAK, pp125 FA kinase, pp125fak, protein tyrosine kinase 2, ptk2; Focal adhesion kinase (FAK) is a cytoplasmic non-receptor protein-tyrosine kinase found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents and is involved in signaling pathways involved in cell motility, proliferation, and apoptosis. FAK is activated by tyrosine phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. FAK plays a potential role in oncogenic transformation resulting in increased kinase activity. |
Antigen
Synthetic peptide corresponding to the internal domain of human Focal Adhesion Kinase 1. |
Genebank Info (Protein)
NP_005598 |
Genebank Info (Nucleotide)
NM_005607 |
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IHC analysis of ductal and lobular epithelium using IMG-71987 at 2 ug/ml. |
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Reference
1. J Pharmacol Exp Ther 2006 Nov.: Microtubule Destabilizing Agents Induce Focal Adhesion Structures Disorganization and Anoikis in Cancer Cells.
Deschesnes RG, Patenaude A, Rousseau JL, Fortin JS, Ricard C, Cote MF, Huot J, C-Gaudreault R, and Petitclerc E
2. J Cell Physiol 2006 Nov.: FAK phosphorylation at Ser-843 inhibits Tyr-397 phosphorylation, cell spreading and migration. Jacamo R, Jiang X, Lunn JA, and Rozengurt E
3. J Biol Chem 2006 Nov.: Repetitive deformation activates FAK and ERK mitogenic signals in human Caco-2 intestinal epithelial cells through Src and Rac1. Chaturvedi LS, Marsh HM, Shang X, Zheng Y, and Basson MD
4. Biochim Biophys Acta 2006 Oct.: Signalling via integrins: Implications for cell survival and anticancer strategies. Hehlgans S, Haase M, and Cordes N
5. Biochim Biophys Acta 2006 Sep.: Activation of human T lymphocytes via integrin signaling induced by RGD-disintegrins. Neto EH, Coelho AL, Sampaio AL, Henriques MD, Marcinkiewicz C, De Freitas MS, and Barja-Fidalgo C
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Research purposes only.
Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.
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