Peptide-affinity Purified Polyclonal Antibody to BACE1/ASP2 (Beta-site APP-cleaving enzyme 1)

Background
Principal Names- ASP2, BACE, EC 3.4.23.46, FLJ90568, HSPC104, KIAA1149, MEMAPSIN-2, APP beta-secretase, asp2, aspartylprotease 2, b-Secretase, bace, bace1, beta-secretase, beta-site amyloid precursor protein cleaving enzyme, beta-site app cleaving enzyme, memapsin-2, membrane-associated aspartic protease 2, transmembrane aspartic proteinase Asp2;  Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Four transcript variants encoding different isoforms have been described for this gene.  Bace 1 is responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.

Antigen
Synthetic peptide corresponding to a region near the N-terminus human Beta-site APP-cleaving enzyme 1 (BACE1).

Application Notes
Peptide sequence used for immunogen is 94% conserved in mouse and 100% conserved in rat.

Genebank Info (Protein)
NP_620429

Genebank Info (Nucleotide)
NM_012104

Reference
1. Bioorg Med Chem Lett 2006 Oct. :  Design of potent inhibitors of human beta-secretase. Part 2.  Freskos JN, Fobian YM, Benson TE, Moon JB, Bienkowski MJ, Brown DL, Emmons TL, Heintz R, Laborde A, McDonald JJ, Mischke BV, Molyneaux JM, Mullins PB, Bryan Prince D, Paddock DJ, Tomasselli AG, and Winterrowd G
2. Neurodegener Dis 2006 . 3:270-4  Amyloid Precursor Protein and BACE Function as Oligomers.  Multhaup G
3. Neurodegener Dis 2006 . 3:262-9  Ectodomain shedding of the amyloid precursor protein: cellular control mechanisms and novel modifiers.  Lichtenthaler SF
4. Neurodegener Dis 2006 . 3:247-54  Control of Amyloid-beta-Peptide Generation by Subcellular Trafficking of the beta-Amyloid Precursor Protein and beta-Secretase.  Walter J
5. Neurodegener Dis 2006 . 3:218-26  Subcellular trafficking of the amyloid precursor protein gene family and its pathogenic role in Alzheimer's disease.  Kins S, Lauther N, Szodorai A, and Beyreuther K