Background
Principal Names: EGFR, EC 2.7.10.1, ERBB, ERBB1, MENA, egf receptor, egf-r, egfr, epidermal growth factor receptor, erbb1, panitumumab, v-erb-b homolog; Epidermal growth factor receptor (EGFR) is a tyrosine protein kinase comprised of two different components of different molecular weights. Both components contain phosphotyrosine and phosphothreonine but only the higher molecular weight component contains phosphoserine. EGFR signaling involves small GTPases of the Rho family and EGFR trafficking involves small GTPases of the Rab family. EGFR expression is widespread in both normal and cancerous tissues. |
