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Product : Antibody >> Chromatin , Phosphospecific Antibodie.. >> c-Jun (Ser73)
      
 

Peptide-affinity Purified Polyclonal Antibody to c-Jun (Ser73)

 
Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
IMG-90120-1
c-Jun (Ser73)Purified, Peptide Affinity
50 µg
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Catalog No: IMG-90120-1
Imgenex is now a part of Novus Biologicals! All orders, billing and shipments will be received from Novus. Please contact Novus directly for any questions novus@novusbio.com. To insure proper processing of you order, please insure that your purchase orders show Novus Biologicals as the vendor.
Contents: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Isotype: Rabbit IgG
Clone: N/A
Purification: Prepared from rabbit serum by affinity purification via sequential chromatography on phospho and dephosphopeptide affinity columns.
Species: Human, Mouse, Rat
Host: Rabbit
Application: IHC (paraffin): 1:50-1:100
Western Blot: 1:500-1:1000
Storage: Store at -20C.
Recommended
Positive Control:
HeLa cells
 

Background
c-Jun is the putative transforming gene of avian sarcoma virus 17. The protein forms a complex with c-Fos, forming the transcription factor AP-1. AP-1 is a generic term for a dimeric transcription factor that contains members from the Jun, Fos, ATF, and MAF protein families. AP-1 complexes recognize the same sequence motif, termed TRE (TPA responsive element), which is also referred to as the AP-1 binding site. AP-1 activity can be regulated by dimer composition, transcription, post-translational modification and interactions with other proteins. AP-1 proteins play key roles in cell proliferation, differentiation, apoptosis, angiogenesis and tumour invasion. The c-Jun gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.

Antigen
This antibody was generated by immunizing rabbits with a synthetic phosphopeptide corresponding to human c-Jun around the phosphorylation site of serine 73 (L-A-SP-P-E).

Genebank Info (Protein): NP_002219
Gene ID: 3725
SwissProt: P05412
 
c-Jun (Ser73) Antibody

Western blot analysis of c-Jun (Ser73) using IMG-90120-1 in HeLa cells.

c-Jun (Ser73) Antibody IMG-90120-1

Immunohistochemical analysis of c-Jun (Ser73) in paraffin-embedded human breast carcinoma tissue using IMG-90120-1.

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Reference
1. Eferl, R. et al. Nat. Rev. Cancer. 3:859-868 (2003).


Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.


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