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Peptide-affinity Purified Polyclonal Antibody to ATF2 (Ser112 or 94) |
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| Catalog No: |
IMG-90149-1 |
| Contents: |
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Isotype: |
Rabbit IgG |
| Clone: |
N/A |
| Purification: |
Prepared from rabbit serum by affinity purification via sequential chromatography on phospho and dephosphopeptide affinity columns. |
| Species: |
Human, Mouse, Rat |
| Host: |
Rabbit |
| Application: |
IHC (paraffin): 1:50-1:100
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| Storage: |
Store at -20°C. |
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Background
The activating transcription factor ATF2 (also called CRE-BP1) binds to both AP-1 and CRE DNA response elements and is a member of the ATF/CREB family of leucine zipper proteins. ATF2 has been implicated in the transcriptional regulation of a number of genes including cytokines, cell cycle control and apoptosis. Various forms of cellular stress, including inflammatory cytokines and UV irradiation, stimulate the transcriptional activity of ATF2. Stress induced ATF-dependent transcription is dependent on phosphorylation of ATF2. Serine 490 and serine 498 are novel phosphorylation sites on ATF2 that have recently been identified. In addition, ATF2 is particularly abundant in the brain and the ATF2 family of transcription factors is considered important substrates of signals upstream of the activation of genes associated with neuronal growth and differentiation. ATF2 expression has also been linked to depression in humans. Human ATF2 gene is mapped to chromosome 2q32. |
Antigen
This antibody was generated by immunizing rabbits with a synthetic phosphopeptide corresponding to human ATF-2 around the phosphorylation site of serine 112 or 94 (D-L-SP-P-L). |
| Genebank Info (Protein): NP_001871 |
| Gene ID: 1386 |
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Immunohistochemical analysis of ATF-2 (Ser112 or 94) in paraffin-embedded human breast carcinoma tissue using IMG-90149-1. |
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Reference
1. Karin, M. et al. Curr. Biol. 5:747-757 (1997).
2. Maekawa, T. et al. EMBO J. 8:2023-2028 (1989).
3. Gutpa, S. Science. 267:389-393 (1995).
4. Bhoumik, A. et al. Proc. Natl. Acad. Sci. U.S.A. 101:4222-4227 (2004).
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Research purposes only.
Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.
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