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Product : Antibody >> Chromatin , Phosphospecific Antibodie.. >> ATF4 (Ser245)
      
 

Peptide-affinity Purified Polyclonal Antibody to ATF4 (Ser245)

 
Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
IMG-90166-1
ATF4 (Ser245)Purified, Peptide Affinity
50 µg
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Catalog No: IMG-90166-1
Imgenex is now a part of Novus Biologicals! All orders, billing and shipments will be received from Novus. Please contact Novus directly for any questions novus@novusbio.com. To insure proper processing of you order, please insure that your purchase orders show Novus Biologicals as the vendor.
Contents: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Isotype: Rabbit IgG
Clone: N/A
Purification: Prepared from rabbit serum by affinity purification via sequential chromatography on phospho and dephosphopeptide affinity columns.
Species: Human
Host: Rabbit
Application: IHC (paraffin): 1:50-1:100
Storage: Store at -20C.
 

Background
ATF4 encodes a cAMP response element (CRE) binding protein called CREB-2 which acts as a transcriptional activator. The protein contains a COOH-terminal leucine-zipper motif and an adjacent basic domain. The protein is expressed ubiquitously in human brain and umbilical vein endothelial cell. The protein binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. The protein is localized in the 22q13.1 region of human chromosome. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication. ATF4 negatively regulate transcription from the cAMP response element.

Antigen
This antibody was generated by immunizing rabbits with a synthetic phosphopeptide corresponding to human ATF4 around the phosphorylation site of serine 245 (N-R-SP-L-P).

Genebank Info (Protein): NP_001666
Gene ID: 468
 
ATF4 (Ser245) Antibody IMG-90166-1

Immunohistochemical analysis of ATF4 (Ser245) in paraffin-embedded human breast carcinoma tissue using IMG-90166-1.

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Reference
1. Karpinski, BA. et al. Proc. Natl. Acad. Sci. U S A. 89:4820-4 (1992).


Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.


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