PATHWAY PROFILING ANTIBODIES & REAGENTS

     
Products
Product : Antibody >> Cell Cycle , DNA Methylation & Rep.. , Phosphospecific Antibodie.. >> BRCA1 (Ser1524)
      
 

Peptide-affinity Purified Polyclonal Antibody to BRCA1 (Ser1524)

 
Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
IMG-90218-1
BRCA1 (Ser1524)Purified, Peptide Affinity
50 µg
 --
 
Catalog No: IMG-90218-1
Imgenex is now a part of Novus Biologicals! All orders, billing and shipments will be received from Novus. Please contact Novus directly for any questions novus@novusbio.com. To insure proper processing of you order, please insure that your purchase orders show Novus Biologicals as the vendor.
Contents: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Isotype: Rabbit IgG
Clone: N/A
Purification: Prepared from rabbit serum by affinity purification via sequential chromatography on phospho and dephosphopeptide affinity columns.
Species: Human
Host: Rabbit
Application: IHC (paraffin): 1:50-1:100
Storage: Store at -20C.
 

Background
The breast cancer tumor-suppressor gene, BRCA1, encodes a protein with a BRCT domain, a motif that is found in many proteins that are implicated in DNA damage response and in genome stability. It combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC for BRCA1-associated genome surveillance complex. BRCA1 functions in the nuclear processes of transcription, chromatin remodeling and silencing, and in various DNA repair mechanisms. It also has ubiquitin ligase activity. It regulates key effectors that control the G2/M checkpoint and is therefore involved in regulating the onset of mitosis. It is a protein of unknown structure and has a few identifiable features. The C-terminus of BRCA1 contains two 95-residue BRCT domains. Pathological role of the protein has been identified in breast and ovarian cancer. Many alternatively spliced transcript variants have been described for this gene with only some have had their full-length natures identified.

Antigen
This antibody was generated by immunizing rabbits with a synthetic phosphopeptide corresponding to human BRCA1 around the phosphorylation site of serine 1524 (Y-P-SP-Q-E).

 
BRCA1 (Ser1524) Antibody IMG-90218-1

Immunohistochemical analysis of BRCA1 (Ser1524) in paraffin-embedded human breast carcinoma tissue using IMG-90218-1.

-

Reference
1. Kashima, K. et al. Jpn. J. Canc. Res. 91:399-409 (2000).
2. Ronit, Y. et al. Nature Genetics. 30:285-289 (2002).


Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.


Products

Services

Resources

Purchasing

Company

  • What's New
  • Reporter Cells
  • Screening Services
  • Interactive Pathways