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Product : Antibody >> Apoptosis , Cancer Antibodies , Cell Cycle , DNA Methylation & Rep.. , NF-kB Pathway >> ATM (Ser1981)
      
 

Peptide-affinity Purified Polyclonal Antibody to ATM (Ser1981)

 
Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
IMG-90221-1
ATM (Ser1981)Purified, Peptide Affinity
50 µg
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Catalog No: IMG-90221-1
Imgenex is now a part of Novus Biologicals! All orders, billing and shipments will be received from Novus. Please contact Novus directly for any questions novus@novusbio.com. To insure proper processing of you order, please insure that your purchase orders show Novus Biologicals as the vendor.
Contents: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Isotype: Rabbit IgG
Clone: N/A
Purification: Prepared from rabbit serum by affinity purification via sequential chromatography on phospho and dephosphopeptide affinity columns.
Species: Human, Mouse
Host: Rabbit
Application: IHC (paraffin): 1:50-1:100
Storage: Store at -20C.
 

Background
ATM belongs to a family of proteins, conserved from yeast to humans that regulate cell-cycle checkpoints and are involved in DNA repair and recombination. The protein has a carboxy-terminal sequence with significant homology to the catalytic domain of phosphatidylinositol-3-OH kinase. In response to DNA damage agents such as ionizing irradiation and chemical agent cisplatin, ATM kinase is activated, leading to a cascade of kinase reactions regulating cell cycle, apoptosis, and DNA damage repair . Besides it also regulates radiation sensitivity, and cellular proliferation. Many downstream target molecules of ATM kinase were so far identified. These target proteins include p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. Mutations in the gene contribute to human cancer-associated diseases ataxia-telangiectasia, T-cell acute lymphoblastic leukemia, B-cell non-Hodgkin lymphomas and B-cell chronic lymphocytic leukemia. Human ATM gene is located on chromosome 11q22-23.

Antigen
This antibody was generated by immunizing rabbits with a synthetic phosphopeptide corresponding to human ATM around the phosphorylation site of serine 1981 (E-G-SP-Q-S).

Genebank Info (Protein): NP_000042
Gene ID: 472
SwissProt: Q13315
 
ATM (Ser1981) Antibody IMG-90221-1

Immunohistochemical analysis of ATM (Ser1981) in paraffin-embedded human breast carcinoma tissue using IMG-90221-1.

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Reference
1. Crawford, TO. et al. Semin. Pediatr. Neurol. 5:287-294 (1998).
2. Peilin, Z. et al. Molecular Cancer. 2:2-5 (2003).


Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.


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