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Peptide-affinity Purified Polyclonal Antibody to Vav (Ab-174) |
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| Catalog No: |
IMG-90486-2 |
| Contents: |
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Isotype: |
Rabbit IgG |
| Clone: |
N/A |
| Purification: |
Prepared from rabbit serum by affinity purification via sequential chromatography on phospho and dephosphopeptide affinity columns. |
| Species: |
Human, Mouse, Rat |
| Host: |
Rabbit |
| Application: |
Western Blot: 1:500-1:1000 |
| Storage: |
Store at -20°C. |
Recommended
Positive Control: |
Jurkat cells |
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Background
Vav, which is predominantly expressed during adult life, is one of the genetic markers that correlate with the differentiation of the hematopoietic cells. Its functional importance has been extensively studied in T and B cells, in which it appears crucial for both development and functions. In non-lymphoid hematopoietic cells, Vav is mainly involved in the response of mature cells to a variety of stimuli that lead to spatial and temporal reorganization of the actin-based cytoskeleton during proliferation and phagocytosis. Vav acts as a potential target for gene therapy of myeloproliferative disorders. Human Vav gene maps to the chromosome 19 in the region 19p13.2. |
Antigen
This antibody was generated by immunizing rabbits with a synthetic non-phosphopeptide corresponding to human Vav around the phosphorylation site of tyrosine 174 (E-I-YP-E-D). |
Genebank Info (Protein)
NP_005419 |
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Western blot analysis of Vav (Ab-174) using IMG-9486-2 in Jurkat cells. |
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Reference
1. Valeria, B. et al. Experimental Cell Research. 306:56-63 (2005).
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Research purposes only.
Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.
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