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Datasheet
Peptide-affinity Purified Polyclonal Antibody to GSK3b (Ab-216)
Cat.No IMG-90581-2
Description GSK3b (Ab-216)
Format Purified, Peptide Affinity
Unit 100 µg
Price(USD) 295.00
MSDS
Catalog No
:
IMG-90581-2
Contents
:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Isotype
:
Rabbit IgG
Clone
:
N/A
Purification
:
Prepared from rabbit serum by affinity purification via sequential chromatography on phospho and dephosphopeptide affinity columns.
Species
:
Human, Mouse, Rat
Host
:
Rabbit
Application
Western Blot: 1:500-1:1000 Storage Store at -20°C. Recommended Positive Control : 293 cells
Background GSK3b is a proline directed serine/threonine kinase, originally identified as a result of its role in glycogen metabolism regulation. GSK3b is particularly abundant in the central nervous system, where it is neuron specific. It affects many fundamental cellular functions, including cell cycle, gene transcription, and cytoskeletal integrity. GSK3b has recently been implicated in many signaling pathways, such as Wnt and PI3/PKB signaling. Recently the pathological role of the protein has been identified in Alzheimer Disease (AD), a neurodegenerative disease. Human GSK3b has been mapped to chromosomal region 3q13.3.
Antigen
This antibody was generated by immunizing rabbits with a synthetic non-phosphopeptide corresponding to human GSK3b around the phosphorylation site of tyrosine 216 (V-S-YP-I-C).
Western blot analysis of GSK3b (Ab-216) (Lanes 1 and 2) using IMG-90581-2 in 293 cells, untreated or treated with insulin (40?M, 30min).
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Related Products
Reference 1. Baolin, L. et al. Transgenic Research. 13:385-396 (2004).
Research purposes only.
Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.
Related Products
Related Product(s) of the Catalog # IMG-90581-2
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IMG-90581-2 [Peptide-affinity Purified Polyclonal Antibody to GSK3b (Ab-216)]
