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Polyclonal Antibody to IL-32 |
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| Catalog No: |
IMX-5931 |
| Contents: |
100 ul of crude rabbit sera with 50% glycerol and 0.025% sodium azide. Sodium azide is highly toxic. |
| Isotype: |
Rabbit Ig |
| Species: |
Human |
| Host: |
Rabbit |
| Application: |
Peptide ELISA: 1:100-1:1000 |
| Storage: |
Store at -20°C. |
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Background
Researchers have indicated that they want access to novel target antibodies quickly to aid in their research. IMGENEX is pleased to be able to offer researchers access to cutting-edge products that are still in the process of characterization/validation. IMGENEX’s ‘IMX’ antibody line is shown by ELISA to bind to the peptide used as immunogen. Investigators should empirically determine the suitability of the antibody, including optimal dilutions, for other applications of interest.
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We cannot guarantee that the yet-to-be-fully validated antibody will work in any application other than in an ELISA against the peptide used as immunogen and therefore cannot offer a refund if the antibody does not work in your application. |
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The antibody is offered at a lower price compared to a more highly validated antibody. |
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We are not able to provide the immunogen for the antibodies, but do provide the amino acid sequence. |
These antibodies are not fully validated and we appreciate your feedback. Customer feedback is used to help generate testing methodologies which can lead to further product validation or withdrawal.
IL-32 is a 234 amino acid protein belonging to the cytokine family and contains a tyrosine sulfation site, three potential N-myristoylation sites, multiple putative phosphorylation sites and an RGD cell-attachment sequence. It plays a role in activation-induced cell death in T cells, production of TNFalpha from macrophage cells and in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF-alpha and IL-8 and activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK. IL-32 appears to play a role in the pathogenesis of human rheumatoid arthritis and is a novel target in autoimmune diseases. It is expressed predominantly in lymphocytes and immune cells. |
Antigen
Amino acids 208-225 (SFQSYGAPRGDKEELTPQ) of human IL-32 protein were used as the immunogen. |
Application Notes
The amino acid sequence used as immunogen is 100% homologous in human (isoform CRA_c and CRA_d). |
| Genebank Info (Protein): NP_001012736 |
| Gene ID: 9235 |
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Reference
1. Goda, C. et al. Int. Immunol. 18:233-240 (2006).
2. Joosten, LA. et al. Proc. Natl. Acad. Sci. USA. 103:3298-3303 (2006).
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Research purposes only.
Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.
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