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Product : Antibody >> Antigen Affinity Purified , DNA Methylation & Rep.. , New Antibodies >> HDAC-7
      
 

Polyclonal Antibody to HDAC-7

 
Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
IMX-5933
HDAC-7Purified, Peptide Affinity
0.1 mg
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Catalog No: IMX-5933
Imgenex is now a part of Novus Biologicals! All orders, billing and shipments will be received from Novus. Please contact Novus directly for any questions – novus@novusbio.com. To insure proper processing of you order, please insure that your purchase orders show Novus Biologicals as the vendor.
Contents: 100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Isotype: Rabbit Ig
Purification: Antigen affinity chromatography
Species: Chimpanzee, Cow, Dog, Horse, Human, New World monkey, Zebrafish
Predicted React: Chicken, Mouse, Rat
Host: Rabbit
Application: Peptide ELISA: 1:100-1:1000
Storage: Store at 4°C, stable for 6 months. For long-term storage, aliquot and store at -20°C
 

Background
Researchers have indicated that they want access to novel target antibodies quickly to aid in their research. IMGENEX is pleased to be able to offer researchers access to cutting-edge products that are still in the process of characterization/validation. IMGENEX’s ‘IMX’ antibody line is shown by ELISA to bind to the peptide used as immunogen. Investigators should empirically determine the suitability of the antibody, including optimal dilutions, for other applications of interest.

We cannot guarantee that the yet-to-be-fully validated antibody will work in any application other than in an ELISA against the peptide used as immunogen and therefore cannot offer a refund if the antibody does not work in your application.
The antibody is offered at a lower price compared to a more highly validated antibody.
We are not able to provide the immunogen for the antibodies, but do provide the amino acid sequence.


These antibodies are not fully validated and we appreciate your feedback. Customer feedback is used to help generate testing methodologies which can lead to further product validation or withdrawal.
Histone deacetylase 7 is a thymus-specific, intracellular, transcription factor belonging to the class IIa histone deacetylase family. Reports suggest that dephosphorylation and nuclear localization of HDAC-7 is promoted by Myosin phosphatase, thus regulating the repression of Nur77 and inhibition of apoptosis in CD4+CD8+ double-positive thymocytes. HDAC-7 plays a specific role in maintaining vascular integrity by repressing the expression of matrix metalloproteinase (MMP) 10. It promotes repression mediated by transcriptional corepressor NCOR2 and is an efficient corepressor of the androgen receptor (AR). It is also responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).

Antigen
Amino acids 313-322 (CLSRTRSEPLP) of human HDAC-7 protein were used as the immunogen.

Application Notes
The amino acid sequence used as immunogen is 100% homologous in human, monkey, cow, dog, chimpanzee and horse, 90% homologous in mouse, chicken and rat.

Genebank Info (Protein): NP_055522
Gene ID: 9734
 
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Reference
1. Dequiedt, F. et al.: Immunity. 18:687-698 (2003).
2. Maribel, P. et al. GENES & DEVELOPMENT. 21:638-643 (2007).
3. Chang, S. et al. Cell. 126:321-334 (2006).


Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.


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