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Polyclonal Antibody to NXP-2 |
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| Catalog No: |
IMX-6193 |
| Contents: |
100 ul of crude rabbit sera with 50% glycerol and 0.025% sodium azide. Sodium azide is highly toxic. |
| Isotype: |
Rabbit Ig |
| Purification: |
Crude Sera |
| Species: |
Human |
| Predicted React: |
Mouse |
| Host: |
Rabbit |
| Application: |
Peptide ELISA*: 1:100-1:1000 |
| Storage: |
Store at -20°C. |
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Background
Researchers have indicated that they want access to novel target antibodies quickly to aid in their research. IMGENEX is pleased to be able to offer researchers access to cutting-edge products that are still in the process of characterization/validation. IMGENEX’s ‘IMX’ antibody line is shown by ELISA to bind to the peptide used as immunogen. Investigators should empirically determine the suitability of the antibody, including optimal dilutions, for other applications of interest.
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We cannot guarantee that the yet-to-be-fully validated antibody will work in any application other than in an ELISA against the peptide used as immunogen and therefore cannot offer a refund if the antibody does not work in your application. |
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The antibody is offered at a lower price compared to a more highly validated antibody. |
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We are not able to provide the immunogen for the antibodies, but do provide the amino acid sequence. |
These antibodies are not fully validated and we appreciate your feedback. Customer feedback is used to help generate testing methodologies which can lead to further product validation or withdrawal.
NXP-2 is a unique mammalian nuclear protein expressed in specific tissues and has specific RNA binding function. NXP-2 is a member of the MORC protein family characterized by conserved structures consisting of a GHL (Gyrase B, Hsp90 and MutL)-ATPase domain at the amino-terminus, a zinc finger type CW domain containing conserved four cysteines and two tryptophans, a nuclear localization signal (NLS) and coiled-coil domains at the carboxy-terminus. The protein is localized in the nucleus and distributed to the nuclear matrix. Apart from RNA binding activity, the protein also plays important roles in diverse nuclear functions, including RNA metabolism and maintenance of nuclear architecture. A recent study has confirmed the role of the protein in SUMO-mediated repression of transcription. NXP-2 also regulates the activity of tumor suppressor protein, p53 and its localization into promyelocytic leukemia (PML)-nuclear bodies. Human NXP-2 gene is located at chromosome 21q22.13. |
Antigen
Amino acids 321-338 (NRLIKAYEKVGCQLRANN) of human NXP-2 protein were used as the immunogen. |
Application Notes
The amino acid sequence used as immunogen is 100% homologous in human and 94% homologous in mouse. |
| Genebank Info (Protein): NP_056173 |
| Gene ID: 23515 |
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Reference
1. Yukio, K. et al. J. Biol. Chem. 277:20611-20617 (2002).
2. Adam, R. et al. PNAS. 103:5308-5313 (2007).
3. Keiko, T. et al. Molecular Biology of the Cell. 18:1701-1709 (2007).
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Research purposes only.
Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.
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