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Product : Antibody >> Development & Differe.. , New Antibodies , Stem Cell Markers >> Dishevelled-3
      
 

Polyclonal Antibody to Dishevelled-3

 
Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
IMX-6234
Dishevelled-3Sera
0.1 mL
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Catalog No: IMX-6234
Imgenex is now a part of Novus Biologicals! All orders, billing and shipments will be received from Novus. Please contact Novus directly for any questions novus@novusbio.com. To insure proper processing of you order, please insure that your purchase orders show Novus Biologicals as the vendor.
Contents: 100 ul of crude rabbit sera with 50% glycerol and 0.025% sodium azide. Sodium azide is highly toxic.
Isotype: Rabbit Ig
Species: Human
Predicted React: Mouse
Host: Rabbit
Application: Peptide ELISA: 1:100-1:1000
Storage: Store at -20C.
 

Background
Researchers have indicated that they want access to novel target antibodies quickly to aid in their research. IMGENEX is pleased to be able to offer researchers access to cutting-edge products that are still in the process of characterization/validation. IMGENEX’s ‘IMX’ antibody line is shown by ELISA to bind to the peptide used as immunogen. Investigators should empirically determine the suitability of the antibody, including optimal dilutions, for other applications of interest.

We cannot guarantee that the yet-to-be-fully validated antibody will work in any application other than in an ELISA against the peptide used as immunogen and therefore cannot offer a refund if the antibody does not work in your application.
The antibody is offered at a lower price compared to a more highly validated antibody.
We are not able to provide the immunogen for the antibodies, but do provide the amino acid sequence.


These antibodies are not fully validated and we appreciate your feedback. Customer feedback is used to help generate testing methodologies which can lead to further product validation or withdrawal.
Dishevelled-3 is one of the three human genes (DVL1, DVL2 and DVL3) encoding proteins homologous to Drosophila dishevelled gene, Dsh. Dsh is a member of the segment polarity gene family in Drosophila which plays an important role in the early developmental patterning processes. Dsh is also required for the specification of cell fate and polarity by secreted Wnt proteins, mediating Wnt signaling. Dishevelled-3 mediates Wnt signaling through three key domains: the DIX domain at the amino terminus, the PDZ domain in the central region, and the DEP domain near the carboxyl terminus. Each of these domains likely mediates protein-protein interactions that allow the Dvl proteins to act as scaffolding proteins during Wnt signaling. Dishevelled-3 is widely expressed in human cells and has a widespread role in signal transduction. Dishevelled-3 mRNA is often detected in normal human breast tissues and tumour. Human Dishevelled-3 gene is localized in the chromosomal region 3q27.

Antigen
Amino acids 120-137 (AGGGSQENLDNDTETDSL) of human Dishevelled-3 protein were used as the immunogen.

Application Notes
The amino acid sequence used as immunogen is 100% homologous in human and 94% homologous in mouse.

Genebank Info (Protein): NP_004414
Gene ID: 1857
SwissProt: Q92997
 
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Reference
1. Bui, TD. et al. Biochem. Biophys. Res. Commun. 239:510-516(1997).
2. Jun, L. et al. Proc. Natl. Acad. Sci. U S A. 102:1927-1932 (2005).


Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.


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