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Polyclonal Antibody to AXL/UFON |
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| Catalog No: |
IMX-6254 |
| Contents: |
100 ul of crude rabbit sera with 50% glycerol and 0.025% sodium azide. |
| Isotype: |
Rabbit Ig |
| Purification: |
Crude rabbit sera |
| Species: |
Dog, Horse, Human, Mouse, Opossum, Rat |
| Predicted React: |
Chicken, Cow, Pig, Xenopus |
| Host: |
Rabbit |
| Application: |
Peptide ELISA*: 1:100-1:1000 |
| Storage: |
Store at -20°C. |
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Background
Researchers have indicated that they want access to novel target antibodies quickly to aid in their research. IMGENEX is pleased to be able to offer researchers access to cutting-edge products that are still in the process of characterization/validation. IMGENEX’s ‘IMX’ antibody line is shown by ELISA to bind to the peptide used as immunogen. Investigators should empirically determine the suitability of the antibody, including optimal dilutions, for other applications of interest.
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We cannot guarantee that the yet-to-be-fully validated antibody will work in any application other than in an ELISA against the peptide used as immunogen and therefore cannot offer a refund if the antibody does not work in your application. |
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The antibody is offered at a lower price compared to a more highly validated antibody. |
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We are not able to provide the immunogen for the antibodies, but do provide the amino acid sequence. |
These antibodies are not fully validated and we appreciate your feedback. Customer feedback is used to help generate testing methodologies which can lead to further product validation or withdrawal.
AXL/UFON is an 887 amino acid proto-oncogene belonging to the protein kinase super family with a protein kinase domain, two Ig-like C2-type (immunoglobulin-like) domains and two fibronectin type–III domains. Unlike other receptor tyrosine kinases, AXL represents a unique novel structure in the extracellular region that juxtaposes IgL and FNIII repeats. AXL may function as a signal transducer between specific cell types of mesodermal origin and may transduce signals from the extracellular matrix into the cytoplasm by binding to growth factors like vitamin K-dependent protein growth-arrest-specific gene 6 (GAS6) and thus form heterodimer and heterotetramer. It plays an important role in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. In the case of filovirus infection, AXL seems to function as a cell entry factor. Studies reveal the transforming potential of AXL in patients with chronic myeloproliferative disorder or chronic myelocytic leukemia. |
Antigen
Amino acids 195-212 of human AXL/UFON
PGLNKTSSFSCEAHNAKG protein were used as the immunogen. |
Application Notes
The amino acid sequence used as immunogen is 100% homologous in human, horse, opossum, rat, dog, mouse and chimpanzee, 94% homologous in pig and cow, 83% homologous in xenopus and 77% homologous in chicken. |
Genebank Info (Protein)
NP_068713.2 |
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Reference
1. Janssen, JWG. et al. Oncogene. 6:2113-2120 (1991).
2. Liu, E. et al. Proc. Nat. Acad. Sci. 85:1952-1956 (1988).
3. O'Bryan, JP. et al. Molec. Cell. Biol. 11:5016-5031 (1991).
4. Varnum, BC. et al. Nature. 373:623-626 (1995).
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Research purposes only.
Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.
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