Datasheet

Polyclonal Antibody to NALP5 Cat.No IMX-6336 Description NALP5 Format Sera Unit 0.1 mL Price(USD) 165.00 MSDS Catalog No : IMX-6336 Contents : 100 ul of crude rabbit sera with 50% glycerol and 0.025% sodium azide. Sodium azide is highly toxic.  Isotype : Rabbit Ig Species : Human Predicted React : Monkey Host : Rabbit Application Peptide ELISA*: 1:100-1:1000 Storage Store at -20°C. Background NALP5 is a 1200 amino acid cytoplasmic protein belonging to the NALP protein family and contains a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). NALP5 plays an important role in embryonic development beyond the two cell stage. Expression of this protein is restricted to oocytes and may have a role in autoimmune premature ovarian failure and infertility in women. Like other members of the family, NALP5 may also play a critical role in the activation of proinflammatory caspases like CASP1 by the formation of multiprotein complexes known as inflammasomes and may also be a cause of neuronal apoptosis following brain injury or diseases. Reports suggest that auto-antibodies against NALP5 which are highly specific may also be useful in the diagnosis of the multiorgan autoimmune disorder autoimmune polyendocrine syndrome type I (APS1).  Antigen Amino acids 215-232 of human NALP5 QEGATAAETEEQGHGGDT protein were used as the immunogen. Application Notes The amino acid sequence used as immunogen is 100% homologous in human ( isoform CRA_b) and 77% homologous in monkey. Genebank Info (Protein) NP_703148   ffsdf Related Products Reference 1. Alimohammadi, M. et al. New Eng. J. Med. 358:1018-1028 (2008). 2. Tong, Z.-B. et al. Hum. Reprod. 17:903-911 (2002). 3. Tschopp, J. et al. Nature Rev. Molec. Cell Biol. 4:95-104 (2003). Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.

Related Products

Related Product(s) of the Catalog # IMX-6336

No related products found.

FAQ

Welcome to the IMGENEX Knowledgebase Center! The IMGENEX Knowledgebase Center is an interactive tool containing hundreds of answers to frequently asked technical questions compiled by IMGENEX technical support scientists. Updated daily, you can quickly find information about specific products and applications.

Searching the IMGENEX Knowledgebase Center You can search the Knowledgebase using two different search methods. To quickly search for all tech notes and inquiries related to a specific keyword or application simply enter a keyword into the search box and click the Search button. To browse technical inquiries by product or category, use the links below to navigate to the appropriate product platform. Search the IMGENEX Knowledgebase by Keyword

IMX-6336 [Polyclonal Antibody to NALP5 ]

Go to 'IMX-6336' Data Sheet

Protocols

Imgenex Protocols

No Result Found...!

e-Booklet

Click Here