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Polyclonal Antibody to NALP8 |
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| Catalog No: |
IMX-6341 |
| Contents: |
100 ul of crude rabbit sera with 50% glycerol and 0.025% sodium azide. Sodium azide is highly toxic. |
| Isotype: |
Rabbit Ig |
| Species: |
Chimpanzee, Human |
| Predicted React: |
New World monkey |
| Host: |
Rabbit |
| Application: |
Peptide ELISA*: 1:100-1:1000
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| Storage: |
Store at -20°C. |
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Background
Researchers have indicated that they want access to novel target antibodies quickly to aid in their research. IMGENEX is pleased to be able to offer researchers access to cutting-edge products that are still in the process of characterization/validation. IMGENEX’s ‘IMX’ antibody line is shown by ELISA to bind to the peptide used as immunogen. Investigators should empirically determine the suitability of the antibody, including optimal dilutions, for other applications of interest.
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We cannot guarantee that the yet-to-be-fully validated antibody will work in any application other than in an ELISA against the peptide used as immunogen and therefore cannot offer a refund if the antibody does not work in your application. |
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The antibody is offered at a lower price compared to a more highly validated antibody. |
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We are not able to provide the immunogen for the antibodies, but do provide the amino acid sequence. |
These antibodies are not fully validated and we appreciate your feedback. Customer feedback is used to help generate testing methodologies which can lead to further product validation or withdrawal.
NALP8, like other NALP proteins, is a cytoplasmic protein that forms a subfamily within the larger CATERPILLER protein family. NALP8 is a short NALP, with an N-terminal pyrin (MEFV) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. Though the exact function of NALP8 is yet unknown reports suggest that it may be involved in the activation of proinflammatory caspases (e.g., CASP1) via their involvement in multiprotein complexes called inflammasomes. |
Antigen
Amino acids 130-147 PEDLNVGETQVNLEEGES of human NALP8 protein were used as the immunogen. |
Application Notes
The amino acid sequence used as immunogen is 100% homologous in human and chimpanzee, and 94% homologous in monkey. |
| Genebank Info (Protein): NP_789781 |
| Gene ID: 126205 |
| SwissProt: Q86W28 |
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Reference
1. Tschopp, J. et al. Nature Rev. Molec. Cell Biol. 4:95-104 (2003).
2. Ponsuksili, S. et al. Biol Reprod. 74:577-584 (2006).
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Research purposes only.
Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.
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