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Product : Antibody >> Chromatin , New Antibodies >> ARRB2
      
 

Polyclonal Antibody to ARRB2

 
Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
IMX-6409
ARRB2Sera
0.1 mL
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Catalog No: IMX-6409
Imgenex is now a part of Novus Biologicals! All orders, billing and shipments will be received from Novus. Please contact Novus directly for any questions novus@novusbio.com. To insure proper processing of you order, please insure that your purchase orders show Novus Biologicals as the vendor.
Contents: 100 ul of crude rabbit sera with 50% glycerol and 0.025% sodium azide. Sodium azide is highly toxic.
Isotype: Rabbit Ig
Purification: Crude rabbit sera
Species: Chimpanzee, Dog, Human, Pig, Rhesus Monkey
Predicted React: Chicken, Cow, Horse, Macaque, Mouse, Pufferfish, Rabbit, Rat
Host: Rabbit
Application: Peptide ELISA*: 1:100-1:1000
Storage: Store at -20C.
 

Background
Researchers have indicated that they want access to novel target antibodies quickly to aid in their research. IMGENEX is pleased to be able to offer researchers access to cutting-edge products that are still in the process of characterization/validation. IMGENEX’s ‘IMX’ antibody line is shown by ELISA to bind to the peptide used as immunogen. Investigators should empirically determine the suitability of the antibody, including optimal dilutions, for other applications of interest.

We cannot guarantee that the yet-to-be-fully validated antibody will work in any application other than in an ELISA against the peptide used as immunogen and therefore cannot offer a refund if the antibody does not work in your application.
The antibody is offered at a lower price compared to a more highly validated antibody.
We are not able to provide the immunogen for the antibodies, but do provide the amino acid sequence.


These antibodies are not fully validated and we appreciate your feedback. Customer feedback is used to help generate testing methodologies which can lead to further product validation or withdrawal.
Beta-arrestin-2 or ARRB2 is a 409 amino acid adaptor protein belonging to the arrestin family with an N- arrestin domain and a C- arrestin domain. ARRB2 is a regulatory protein involved in heterotrimeric G protein-coupled receptor desensitization and is known to regulate beta-adrenergic receptor A function, thus enhancing beta2AR receptor-mediated nuclear translocation of ERK. It binds to phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate G(S) proteins. Along with AIP4, ARRB2 acts as an endosomal sorting molecule that mediates CXCR4 entry into a degradative pathway. It may also be involved in hormone-specific desensitization of TSH receptors.  ARRB2 is a Ca2+ binding protein of the retinal outer segments and binds to P-rhodopsin and is also involved in synaptic transmission in photoreceptor cells. ARRB2 is widely expressed in most tissues, particularly neuronal tissues and spleen.

Antigen
Amino acids 281-298 DNREKRGLALDGKLKHED of human ARRB2 protein were used as the immunogen.

Application Notes
The amino acid sequence used as immunogen is 100% homologous in human, pig, platypus, chimpanzee, dog and rhesus monkey and 94% homologous in cow, horse, rat, opossum, zebrafish, macaque, mouse, pufferfish, rabbit, chicken and Xenopus.

Genebank Info (Protein): P32121
Gene ID: 409
 
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Reference
1. Attramadal, H. et al. J. Biol. Chem. 267:17882-17890 (1992).
2. Alloway, PG. et al. Neuron. 28:129-138 (2000).
3. Chen, W. et al. Science. 301:1394-1397 (2003).
4. Chen, W. et al. Science. 306:2257-2260 (2004).


Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.


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