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Datasheet
Polyclonal Antibody to NALP10
Cat.No IMX-6411
Description NALP10
Format Sera
Unit 0.1 mL
Price(USD) 165.00
MSDS
Catalog No
:
IMX-6411
Contents
:
100 ul of crude rabbit sera with 50% glycerol and 0.025% sodium azide. Sodium azide is highly toxic.
Isotype
:
Rabbit Ig
Purification
:
Crude rabbit sera
Species
:
Human
Predicted React
:
Horse, Rhesus Monkey
Host
:
Rabbit
Application
Peptide ELISA*: 1:100-1:1000 Storage Store at -20°C.
Background NALP10, a regulatory protein of the innate immune system, forms a large signal-induced multiprotein complex, the inflammasome, which activates the pro-inflammatory caspases, caspase-1 and caspase-5. A member of the NALP protein family, NALP10, unlike other members of the family, lacks the LRR (leucine rich repeat) region but contains a DAPIN domain and a NACHT domain. Immunoprecipitation reports suggest that NALP10 interacted with ASC, CASP1, and IL-1B and inhibits NF-kB activation, CASP1/caspase-1-dependent IL-1B secretion and apoptosis induced by ASC (PYCARD) in a dose-dependent manner. Expression of NALP10 is enhanced by stimulation with lipopolysaccharide. Experiments on NALP10 suggest that it acts as a multifunctional negative regulator of inflammation and apoptosis. Wide expression of NALP10 is reported with highest levels in heart, brain and skeletal muscle.
Antigen
Amino acids 329-345 TDEKQADRAFDIVQKND of human NALP10 protein were used as the immunogen.
Application Notes
The amino acid sequence used as immunogen is 100% homologous in human, 88% homologous in rhesus monkey and 82% homologous in horse.
Reference 1. Tschopp, J. et al. Nature Rev. Molec. Cell Biol. 4:95-104 (2003). 2. Wang, Y. et al. Int. Immun. 16:777-786 (2004).
Research purposes only.
Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.
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