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Polyclonal Antibody to DTX1 |
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| Catalog No: |
IMX-6649 |
| Contents: |
100 ul of crude rabbit sera with 50% glycerol and 0.025% sodium azide. Sodium azide is highly toxic. |
| Isotype: |
Rabbit Ig |
| Purification: |
Crude rabbit sera |
| Species: |
Human, Mouse, Rat |
| Host: |
Rabbit |
| Application: |
Peptide ELISA*: 1:100-1:1000 |
| Storage: |
Store at -20°C. |
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Background
Researchers have indicated that they want access to novel target antibodies quickly to aid in their research. IMGENEX is pleased to be able to offer researchers access to cutting-edge products that are still in the process of characterization/validation. IMGENEX’s ‘IMX’ antibody line is shown by ELISA to bind to the peptide used as immunogen. Investigators should empirically determine the suitability of the antibody, including optimal dilutions, for other applications of interest.
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We cannot guarantee that the yet-to-be-fully validated antibody will work in any application other than in an ELISA against the peptide used as immunogen and therefore cannot offer a refund if the antibody does not work in your application. |
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The antibody is offered at a lower price compared to a more highly validated antibody. |
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We are not able to provide the immunogen for the antibodies, but do provide the amino acid sequence. |
These antibodies are not fully validated and we appreciate your feedback. Customer feedback is used to help generate testing methodologies which can lead to further product validation or withdrawal.
Protein deltex-1 is a Notch Signaling Pathway protein which belongs to the Deltex Family of proteins. It contains one RING-type zinc finger and two WWE domains. DTX1 acts as regulator of Notch signaling and has functional significance in cell-fate determinations. It mediates the antineural activity of Notch by inhibiting the transcriptional activation mediated by MATCH1. It is involved in neurogenesis, lymphogenesis, myogenesis and MZB (Marginal Zone B) cell differentiation. It promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1. It functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. DTX1, along with DTX2 and DTX3, functions as E3 ligases based on their capacity for self ubiquitination. |
Antigen
Amino acids 583-599 KTEFGSNLTGHGYPDAS of human DTX1 protein were used as the immunogen. |
Application Notes
The amino acid sequence used as immunogen is 100% homologous in human, mouse and rat. |
Genebank Info (Protein)
Q86Y01 |
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Reference
1. Takeyama, K. et al. J Biol Chem. 278:21930-21937 (2003).
2. Izon, DJ. et al. Immunity. 16:231-243 (2002).
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Research purposes only.
Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.
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