Background
BSE, also known as prion protein, is a membrane glycosylphosphatidylinositol-anchored glycoprotein belonging to the prion family of proteins and is responsible for several transmissible neurodegenerative spongiform encephalopathies. Though the exact function of BSE is not clear, reports suggest that it has a tendency to aggregate forming polymers known as rods and might act as a signaling neurotransmitter. BSE acts as a potent anti-apoptotic protein against BAX-mediated cell-death. Expression is higher in the brain of humans and animals infected with several degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), and transmissible mink encephalopathy (TME). Aberration in this protein is also associated with fatal familial insomnia and Huntington disease-like 1. The following antibodies are included in this BSE antibody bundle:
IMG-5122A Format: Purified Rabbit IgG polyclonal antibody; Application: western blot; Immunogen: amino acids 142-148
IMG-5123A Format: Purified Rabbit IgG polyclonal antibody; Application: western blot; Immunogen: amino acids 162-170
IMG-5124A Format: Purified Rabbit IgG polyclonal antibody; Application: western blot; Immunogen: amino acids 217-229
IMX-5174 Format: Rabbit sera; Application: ELISA; Immunogen: amino acids 79-97 |
