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| Monoclonal Antibody to IL-17F (Clone 4H450) Azide-Free |
| Catalog No |
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IMG-6578E-1MG |
| Contents |
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IL-17F monoclonal antibody in sterile filtered PBS |
| Isotype |
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Mouse IgG1, Kappa |
| Clone |
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4H450 |
| Purification |
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Protein G Chromatography |
| Species React |
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Human |
| Host |
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Mouse |
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| Application
Western blot analysis: 0.2-2 ug/ml
Storage
Store IL-17F antibody at 4°C, stable for 6 months. For long-term storage, aliquot and store antibody at -20°C.
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Background
Interleukin 17 (IL-17) is a pro-inflammatory cytokine produced by a subset of T helper cells that develops distinct from the Th1- and Th2- cell differentiation pathways. IL-17, also known as CTLA-8, stimulates induction of other pro-inflammatory cytokines TNF alpha, IL-1 beta, IL-6, and IL-8, and reports strongly suggest the involvement of IL-17 in several chronic inflammatory diseases such as rheumatoid arthritis, psoriasis and multiple sclerosis. TGF-ß (differentiation) and IL-23 (expansion) are required for induction and maintenance of Th17 (IL-17 producing) cells, which in turn induce the other pro-inflammatory cytokines. IL-17 (~32kDa) protein is produced and exists as a homo-dimer, has homology to a herpes virus early protein, is one of the six members (IL-17A-F) of this cytokine family, and is well characterzed and highly expressed by activated effector memory T cells. |
Antigen
Full-length recombinant human IL-17F was used as the immunogen for this antibody.
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Genebank Info (Protein)
NP_443104
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Western blot analysis of IL-17F in 1) human, 2) mouse and 3) rat full-length recombinant IL-17F protein (20 ng/lane) using IL-17F antibody at 0.2 ug/ml. |
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Reference
1. Mangan PR et al 2006 Nature 441: 231-234
2. Veldhoen M et al 2006 Immunity 24:179-189
3. Chen Z and O’Shea JJ 2008 Immunol Res 41: 87-102
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