Hydrogen peroxide activates NF-kB through tyrosine phosphorylation of IkBa and serine phosphorylation of p65: evidence for the involvement of IkBa kinase and Syk protein tyrosine kinase. Yasunari Takada, Asok Mukhopadhyay, Gopal C. Kundu, Ganapati H. Mahabeleshwar, Sujay Singh, and Bharat B. Aggarwal. J. Biol. Chem., 278: 24233-24241 (2003).
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Activation of p53 by oxidative stress involves PDGF receptor-mediated ATM kinase activation. Kai Chen, Adam Albano, Alan Ho, and John F. Keaney., Jr. J. Biol. Chem., 278: 3952-39533 (2003).
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Anomalous Expression of Epithelial Differentiation-determining GATA Factors in Ovarian Tumorigenesis. Callinice D. Capo-chichi, Isabelle H. Roland, Lisa Vanderveer, Rudi Bao, Tetsuya Yamagata, Hisamaru Hirai, Cynthia Cohen, Thomas C. Hamilton, Andrew K. Godwin, and Xiang-Xi Xu. Cancer Res., 63: 4967-4977 (2003).
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GIPC binds to the human lutropin receptor (LHR) through an unusual PDZ domain binding motif and it regulates the sorting of the internalized human choriogonadotropin (hCG) and the density of cell surface LHR. Takashi Hirakawaa, Colette Galeta, Mikiko Kishi and Mario Ascoli. J. Biol. Chem. 278: 49348-49357 (2003).
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AIP is a mitochondrial import mediator that binds to both import receptor Tom20 and preproteins. Masato Yano, Kazeutoyo Terada, and Masataka Mori. J. Cell. Biol. 163: 45-56 (2003).
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p38 Gamma MAPK Regulation of Glucose Transporter Expression and Glucose Uptake in L6 Myotubes and Mouse Skeletal Muscle. Richard C. Ho, Oscar Alcazar, Nobuharu Fujii, Michael F. Hirshman, Laurie J. Goodyear. Articles in Press. Am J Physiol Regul Integr Comp Physiol (October 30, 2003)10.1152/ajpregu.00563.2003.
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IL-4-Stat6 Signaling Induces Tristetraprolin Expression and Inhibits TNF-{alpha} Production in Mast Cells. Kotaro Suzuki, Hiroshi Nakajima, Kei Ikeda, Yuko Maezawa, Akira Suto, Hiroaki Takatori, Yasushi Saito, and Itsuo Iwamoto.J. Exp. Med. published 24 November 2003, 10.1084/jem.20031701.
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TRADD interacts with STAT1-a and influences interferon-g signaling. Duane R Wesemann, Hongwei Qin, Natalia Kokorina & Etty N Benveniste. Nature Immunology, 5, 199-207 (2004). (Generation of stable cell lines).
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Downregulation of WOX1 induces Tau phosphorylation in vitro: A potential role in Alzheimer's disease. Chun-I Sze, Meng Su, Subbiah Pugazhenthi, Purevsuren Jambal, Li-Jin Hsu, John Heath, Lori Schultz, and Nan-Shan Chang. J. Biol. Chem. 279: 30498-30506 (2004). (Generation of stable cell lines).
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A Novel Role for Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 as a Determinant of Gemcitabine Chemoresistance in Pancreatic Adenocarcinoma Cells. Mark S. Duxbury, Hiromichi Ito, Eric Benoit, Talat Waseem, Stanley W. Ashley, and Edward E. Whang.
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SENP1 Enhances Androgen Receptor-Dependent Transcription through Desumoylation of Histone Deacetylase 1. Jinke Cheng, Dachun Wang, Zhengxin Wang, and Edward T. H. Yeh. Mol. Cell. Biol., 24: 6021-6028 (2004).
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Inhibition of ABCB1 (MDR1) and ABCB4 (MDR3) expression by small interfering RNA and reversal of paclitaxel resistance in human ovarian cancer cells. Zhenfeng Duan, Katherine A. Brakora, and Michael V. Seiden. Mol. Cancer Ther., Jul 2004; 3: 833-838.
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The DNA double-stranded break repair protein endo-exonuclease as a therapeutic target for cancer. Terry Y-K. Chow, Moulay A. Alaoui-Jamali, Chiaoli Yeh, Leonard Yuen, and David Griller. Mol. Cancer Ther., Aug 2004; 3: 911-920.
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CEACAM6 is a determinant of pancreatic adenocarcinoma cellular invasiveness. M S Duxbury, H Ito, E Benoit, S W Ashley, E E Whang. British Journal of Cancer advance online publication Full Paper.
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Atypical protein kinase C stimulates nucleotide excision repair activity. Thierry Louat, Yvan Canitrot, Sandra Jousseaume, Caroline Baudouin, Pierre Canal, Guy Laurent, Dominique Lautier. FEBS Letters 574: 121–125 (2004).
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B-Myb and C-Myb Play Required Roles in Neuronal Apoptosis Evoked by Nerve Growth Factor Deprivation and DNA Damage. David X. Liu, Subhas C. Biswas, and Lloyd A. Greene. J. Neurosci., 24: 8720-8725 (2004).
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The function of mitogen-activated protein kinase phosphatase-1 in peptidoglycan-stimulated macrophages. Edward G. Shepherd, Qun Zhao, Stephen E. Welty, Thomas N. Hansen, Charles V. Smith, and Yusen Liu. J. Biol. Chem., Oct 2004; 10.1074/jbc.M408444200.
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Expression of Ngal regulates epithelial morphogenesis in vitro. Jane A. Gwira, Feng Wei, Shuta Ishibe, Joseph M. Ueland, Jonathan Barasch, and Lloyd G. Cantley. J. Biol. Chem., Jan 2005; 10.1074/jbc.M413192200. (Permanent cell line).
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Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis. Joanne L. Yu, Linda May, Vladimir Lhotak, Siranoush Shahrzad, Senji Shirasawa, Jeffrey I. Weitz, Brenda L. Coomber, Nigel Mackman, and Janusz W. Rak. Blood 105: 1734-1741 (2005).
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Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism. Cullen M. Taniguchi, Kohjiro Ueki, and C. Ronald Kahn. J. Clin. Invest., Feb 2005; 10.1172/JCI200523187.
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Differential regulation of c-Jun-dependent transcription By SUMO-specific proteases. Jinke Cheng, Neil D. Perkins, and Edward T. H. Yeh.
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Sam68 is absolutely required for Rev function and HIV-1 production. Suhasini Modem, Kameswara R. Badri, Thomas C. Holland, and Thipparthi R. Reddy. Nucleic Acids Res., 33: 873-879 (2005).
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Role for the pleckstrin homology domain-containing protein CKIP-1 in AP-1 regulation and apoptosis. Lingqiang Zhang, Guichun Xing, Yi Tie, Ying Tang, Chunyan Tian, Li Li, Libo Sun, Handong Wei, Yunping Zhu, and Fuchu He. EMBO J., Feb 2005; 10.1038/sj.emboj.7600532.
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Expression of Neutrophil Gelatinase-associated Lipocalin Regulates Epithelial Morphogenesis in Vitro. Jane A. Gwira, Feng Wei, Shuta Ishibe, Joseph M. Ueland, Jonathan Barasch, and Lloyd G. Cantley. J. Biol. Chem., 280: 7875-7882 (2005). (permanent cell line)
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TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-B pathway by TRAF-binding TNFRs. Julia Hauer, Stephanie Püschner, Parameswaran Ramakrishnan, Ute Simon, Martina Bongers, Christine Federle, and Hartmut Engelmann. PNAS, 102: 2874-2879 (2005).
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The Haploinsufficient Tumor Suppressor p18 Upregulates p53 via Interactions with ATM/ATR. Bum-Joon Park, Jin Wook Kang, Sang Won Lee, So-Jung Choi, Young Kee Shin, Young Ha Ahn, Yun Hee Choi, Dongho Choi, Kwang Soo Lee and Sunghoon Kim. Cell 120 (2): 209-221 (2005).
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A Role for Mixed Lineage Kinases in Regulating Transcription Factor CCAAT/Enhancer-binding Protein--dependent Gene Expression in Response to Interferon g. Sanjit K. Roy, Jon D. Shuman, Leonidas C. Platanias, Paul S. Shapiro, Sekhar P. M. Reddy, Peter F. Johnson, and Dhananjaya V. Kalvakolanu.
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Intracellular multiplication of Legionella pneumophila depends on host cell amino acid transporter SLC1A5. Hagen Wieland, Susanne Ullrich, Florian Lang and Birgid Neumeister. Molecular Microbiology, 55 (5): 1528 (2005).
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Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. Yu-Hua Tseng, Atul J. Butte, Efi Kokkotou, Vijay K. Yechoor, Cullen M. Taniguchi, Kristina M. Kriauciunas, Aaron M. Cypess, Michio Niinobe, Kazuaki Yoshikawa, Mary Elizabeth Patti & C. Ronald Kahn. Nature Cell Biology 7, 601-611 (2005).
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Up-Regulation of TWIST in Prostate Cancer and Its Implication as a Therapeutic Target. Wai Kei Kwok, Ming-Tat Ling, Tak-Wing Lee, Tracy C.M. Lau, Chun Zhou, Xiaomeng Zhang, Chee Wai Chua, Kwok W. Chan, Franky L. Chan, Carlotta Glackin, Yong-Chuan Wong, and Xianghong Wang. Cancer Res., 65: 5153-5162 (2005).
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Ouabain-induced endocytosis of the plasmalemmal Na/K-ATPase in LLC-PK1 cells requires caveolin-1. Jiang Liu, Man Liang, Lijun Liu, Deepak Malhotra, Zijian Xie, and Joseph I. Shapiro. Kidney International, 67 (5): 1844 (2005) (sold by Biocarta)
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The N-end rule ubiquitin-conjugating enzyme, HR6B, is up-regulated by nerve growth factor and required for neurite outgrowth. Pujan Kavakebi, Barbara Hausott, Andre Tomasino, Shota Ingorokva and Lars Klimaschewski. Molecular and Cellular Neuroscience, 29 (4): 559-568 (2005).
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hMutSá is Protected from Ubiquitin-proteasome-dependent Degradation by Atypical Protein Kinase Cæ Phosphorylation. He´le`ne Hernandez-Pigeon, Anne Quillet-Mary, Thierry Louat, Alexia Schambour, Odile Humbert, Janick Selves, Bernard Salles, Guy Laurent and Dominique Lautier. Journal of Molecular Biology, 348 (1): 63-74 (2005).
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Stable suppression of MDR1 gene expression and function by RNAi in Caco-2 cells. T. Celius, P. Garberg and B. Lundgren. Biochemical and Biophysical Research Communications, Volume 324 (1): 365-371 (2004). (Permanent Cell line)
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Protein kinase C ¦Æ associates with death inducing signaling complex and regulates Fas ligand-induced apoptosis. Ingrid Leroy, Aur¨¦lie de Thonel1, Guy Laurent and Anne Quillet-Mary. Cellular Signalling, 17 (9): 1149-1157 (2005).
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Rad50 depletion impacts upon ATR dependent DNA damage responses. Hui Zhong, Alyson Bryson, Mark Eckersdorff, and David O. Ferguson.Hum. Mol. Genet., 14: 2685-2693 (2005).
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Bim Is a Direct Target of a Neuronal E2F-Dependent Apoptotic Pathway. Subhas C. Biswas, David X. Liu, and Lloyd A. Greene. J. Neurosci., 25: 8349-8358 (2005).
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LAPF, representative of a novel family of PH and FYVE domain-containing proteins, induces caspase-independent apoptosis via lysosomal-mitochondrial pathway. Wei Chen, Nan Li, Taoyong Chen, Yanmei Han, Changfei Li, Yuzhen Wang, Weigang He, Lihuang Zhang, Tao Wan, and Xuetao Cao. J. Biol. Chem., Sep 2005; 10.1074/jbc.M502190200.
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Down-Regulation of Vascular Endothelial Cell Growth Factor-C Expression Using Small Interfering RNA Vectors in Mammary Tumors Inhibits Tumor Lymphangiogenesis and Spontaneous Metastasis and Enhances Survival. Zhengtang Chen, Michelle L. Varney, Matthew W. Backora, Kenneth Cowan, Joyce C. Solheim, James E. Talmadge, and Rakesh K. Singh. Cancer Res., 65: 9004-9011 (2005). (permanent cell line)
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WOX1 is essential for TNF-, UV light-, staurosporine-, and P53-mediated cell death and its tyrosine 33 phosphorylated form binds and stabilizes serine 46-phosphorylated P53. Nan-Shan Chang, Joan Doherty, Amy Ensign, Lori Schultz, Li-Jin Hsu, and Qunying Hong. J. Biol. Chem., Oct 2005; 10.1074/jbc.M505590200.
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Silencing of Human Phosphatidylethanolamine-Binding Protein 4 Sensitizes Breast Cancer Cells to Tumor Necrosis Factor-a–Induced Apoptosis and Cell Growth Arrest. Xiaojian Wang, Nan Li, Hongzhe Li, Bin Liu, Jianming Qiu, Taoyong Chen, and Xuetao Cao. Clin. Cancer Res., 11: 7545-7553 (2005).
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Identification & Characterization of a Novel IGFBP5 Interacting Protein (IGFBP5-IP):Evidence IGFBP5-IP is a Potential Regulator of Osteoblast Cell Proliferation. Yousef G Amaar, Blanca Tapia, Shin-Tai Chen, David J Baylink, and Subburaman Mohan. Am J Physiol Cell Physiol, Nov 2005; 10.1152/ajpcell.00563.2004.
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RNA-dependent integrin 3 protein localization regulated by the Muscleblind-like protein MLP1. Yair Adereth, Vincent Dammai, Nurgun Kose, Runzhao Li & Tien Hsu. Nature Cell Biology, 6 November 2005; | doi:10.1038/ncb1335
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Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation. Meng Qiao, Paul Shapiro, Matthew Fosbrink, Horea Rus, Rakesh Kumar, and Antonino Passaniti. J. Biol. Chem., Jan 2006; 10.1074/jbc.M508162200.
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Calmodulin-Dependent Activation of iNOS in RAW 264.7 Macrophages. Thomas J Weber, Heather S Smallwood, Loel E Kathmann, Lye Meng Markillie, Thomas C Squier, and Brian D Thrall. Am J Physiol Cell Physiol, Jan 2006; 10.1152/ajpcell.00527.2005.(Stable cell line)
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Silencing of the Laminin g-1 Gene Blocks Trypanosoma cruzi Infection. Pius N. Nde, Kaneatra J. Simmons, Yuliya Y. Kleshchenko, Siddharth Pratap, Maria F. Lima, and Fernando Villalta. Infect. Immun., 74: 1643-1648 (2006).
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Endocytic function of Von Hippel-Lindau tumor suppressor protein regulates surface localization of FGF receptor 1 and cell motility
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Knockdown of Skp2 by siRNA inhibits melanoma cell growth in vitro and in vivo. Journal of Dermatological Science, In Press, Corrected Proof, Available online 28 February 2006.
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TRAF6 Regulates Cell Fate Decisions by Inducing Caspase 8-dependent Apoptosis and the Activation of NF-kB. Liusheng He, Xiaoli Wu, Richard Siegel, and Peter E. Lipsky. J. Biol. Chem., 281: 11235-11249 (2006).
Integrin â1 silencing in osteoblasts alters substrate-dependent responses to 1,25-dihydroxy vitamin D3. Liping Wang, Ge Zhao, Rene Olivares-Navarrete, Bryan F. Bell, Marco Wieland, David L. Cochran, Zvi Schwartz and Barbara D. Boyan.Biomaterials, 27 (20): 3716-3725 (2006).
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Early Embryonic Lethality Due to Targeted Inactivation of DNA Ligase III. Nahum Puebla-Osorio, Devin B. Lacey, Frederick W. Alt, and Chengming Zhu
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TonEBP/OREBP is a regulator of nucleus pulposus cell function and survival in the intervertebral disc. Tsung-Ting Tsai, Keith G. Danielson, Asha Guttapalli, Erbil Oguz, Todd J. Albert, Irving M. Shapiro, and Makarand V. Risbud. J. Biol. Chem., Jun 2006; 10.1074/jbc.M601969200.
The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway. Hui-Jye Chen, Chung-Ming Lin, Chyuan-Sheng Lin, Raul Perez-Olle, Conrad L. Leung, and Ronald K.H. Liem. Genes & Dev.,20: 1933-1945 (2006).
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Regulation of E-cadherin and TGF-b3 expression by CD24 in cultured oral epithelial cells. P. Ye, M.A. Nadkarni and N. Hunter. Biochemical and Biophysical Research Communications, In Press, Uncorrected Proof, Available online 14 August 2006,
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Stat5 Expression Is Required for IgE-Mediated Mast Cell Function. Brian O. Barnstein, Geqiang Li, Zhengqi Wang, Sarah Kennedy, Charles Chalfant, Hiroshi Nakajima, Kevin D. Bunting, and John J. Ryan. J. Immunol., 177: 3421-3426 (2006).
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RalB GTPase-Mediated Activation of the IêB Family Kinase TBK1 Couples Innate Immune Signaling to Tumor Cell Survival. Chien, Sungchan Kim, Ron Bumeister, Yueh-Ming Loo, Sung Won Kwon, Cynthia L. Johnson, Mirey G. Balakireva, Yves Romeo, Levy Kopelovich, Michael Gale et al. Cell, Volume 127 (1): 157-170(2006). (Stable cell lines)
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Overexpression of Glycosylphosphatidylinositol (GPI) Transamidase Subunits Phosphatidylinositol Glycan Class T and/or GPI Anchor Attachment 1 Induces Tumorigenesis and Contributes to Invasion in Human Breast Cancer. Guojun Wu, Zhongmin Guo, Aditi Chatterjee, Xin Huang, Ethel Rubin, Feng Wu, Elizabeth Mambo, Xiaofei Chang et al. Cancer Res.,66: 9829-9836 (2006).
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IKKß programs to turn on the GADD45–MKK4–JNK apoptotic cascade specifically via p50 NF-kB in arsenite response. Lun Song, Jingxia Li, Dongyun Zhang, Zheng-gang Liu, Jianping Ye, Qimin Zhan, Han-Ming Shen, Matt Whiteman, and Chuanshu Huang. J. Cell Biol., 175: 607-617 (2006).
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p85a Acts as a Novel Signal Transducer for Mediation of Cellular Apoptotic Response to UV Radiation. Lun Song, Jingxia Li, Jianping Ye, Gang Yu, Jin Ding, Dongyun Zhang, Weiming Ouyang, Zigang Dong, Sung O. Kim, and Chuanshu Huang. Mol. Cell. Biol., Jan 2007; 10.1128/MCB.00657-06.
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Role of p53 in antioxidant defense of HPV-positive cervical carcinoma cells following H2O2 exposure. Boxiao Ding, Sung Gil Chi, Se Heon Kim, Suki Kang, Jae Ho Cho, Dong Su Kim, and Nam Hoon Cho. J. Cell Sci., 120: 2284-2294 (2007).
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LKB1/STK11 supresses cyclooxgenase-2 induction and cellular invasion through PEA3 in lung cancer. Upadhyay S, C Liu, A Chatterjee, M Hoque, M Sook Kim, J Engles, W Westra, B Trink, E Ratovitski, D Sidransky. Cancer Research 66: 7870-7879 (2006). Imgenex Products Cited (H1299 human lung cancer cells): 1. Z-VAD-FMK [pan-caspase inhibitor (IMI-2310-1/5], Fig 4C 2. pSuppressorNeo (IMG-800), Fig 7
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An aggregate-inducing periperin isoform generated through intron retention is upregulated in amytrophic lateral sclerosis and associated with disease pathology. Xiao S, S Tjostheim, T Sanelli, J McLean, P Horne, Y Fan, J Ravits, M Strong, J Robertson. J Neurosci 28:1833-1840 (2008). siRNA sequences for Per 3,4 were transfected into human adrenal carcinomal cell line SW13 cells.
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Inhibition of cell proliferation of Tenon's capsule fibroblast by s-phase kinase-interacting protein 2 targeting SiRNA through increasing p27 protein level. Wang F, L Qi, Y Su, Q Yan, Y Teng. siRNA sequences transfected into primary rabbit eye fibroblasts. siRNA knockdown was assesed by WB, Fig 2D and Fig 3D.
