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|Quinacrine is a weak base which can partition into acidic vesicles such as endosomes and lysosomes, resulting in inhibition of endosomal acidification and lysosomal enzyme activity. Because acidic pH of endosomes is a prerequisite of endosomal TLR activation, quinacrine can serve as an antagonist for endosomal TLRs. Quinacrine and its analog chloroquine are also known to act as therapeutic agents for autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus, of which therapeutic activity is due to suppression of TLR9 activity as shown by researchers.|
Product Handling Protocol
1. To make 100 mM stock solution, dissolve 200 mg quinacrine in 4.2 ml water by gentle vortex.
Note: See our validation tests using the IML-109 (quinacrine sensitive) and IML-102 (quinacrine insensitive) cell lines as shown in Figures 1 and 2.
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|Research purposes only. Not for diagnostic or in vivo use.|