Product : Antibody >> Th17 Antibodies >> IL-17F

Monoclonal Antibody to IL-17F (Clone 4H450) Azide-Free

Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
0.1 mg (0.5 mg/ml)
0.5 mg (1 mg/ml)
1 mg (1 mg/ml)
Catalog No: IMG-6578E-100
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Contents: IL-17F monoclonal antibody in sterile filtered PBS
Isotype: Mouse IgG1, Kappa
Clone: 4H450
Purification: Protein G Chromatography
Species: Human
Host: Mouse
Application: Western blot analysis: 0.2-2 ug/ml
Storage: Store IL-17F antibody at 4C, stable for 6 months. For long-term storage, aliquot and store antibody at -20C.

Interleukin 17 (IL-17) is a pro-inflammatory cytokine produced by a subset of T helper cells that develops distinct from the Th1- and Th2- cell differentiation pathways. IL-17, also known as CTLA-8, stimulates induction of other pro-inflammatory cytokines TNF alpha, IL-1 beta, IL-6, and IL-8, and reports strongly suggest the involvement of IL-17 in several chronic inflammatory diseases such as rheumatoid arthritis, psoriasis and multiple sclerosis. TGF- (differentiation) and IL-23 (expansion) are required for induction and maintenance of Th17 (IL-17 producing) cells, which in turn induce the other pro-inflammatory cytokines. IL-17 (~32kDa) protein is produced and exists as a homo-dimer, has homology to a herpes virus early protein, is one of the six members (IL-17A-F) of this cytokine family, and is well characterzed and highly expressed by activated effector memory T cells.

Full-length recombinant human IL-17F was used as the immunogen for this antibody.

Genebank Info (Protein): NP_443104
Gene ID: 112744
SwissProt: Q96PD4
IL-17F Antibody

Western blot analysis of IL-17F in 1) human, 2) mouse and 3) rat full-length recombinant IL-17F protein (20 ng/lane) using IL-17F antibody at 0.2 ug/ml.


1. Chen Z and O’Shea JJ 2008 Immunol Res 41: 87-102
2. Mangan PR et al 2006 Nature 441: 231-234
3. Veldhoen M et al 2006 Immunity 24:179-189

Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.






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